Publications

Kabir ZD, Lourenco F, Byrne ME, Katzman A, Lee F, Rajadhyaksha AM, Kosofsky BE.  2012.  Brain-derived neurotrophic factor genotype impacts the prenatal cocaine-induced mouse phenotype.. Dev Neurosci. 34(2-3):184-97.

Schierberl K, Giordano T, Satpute S, Hao J, Kaur G, Hofmann F, Moosmang S, Striessnig J, Rajadhyaksha A.  2012.  Cav 1.3 L-type Ca ( 2+) channels mediate long-term adaptation in dopamine D2L-mediated GluA1 trafficking in the dorsal striatum following cocaine exposure.. Channels (Austin). 6(1):11-7.

Lee AS, Ra S, Rajadhyaksha AM, Britt JK, De Jesus-Cortes H, Gonzales KL, Lee A, Moosmang S, Hofmann F, Pieper AA et al..  2012.  Forebrain elimination of cacna1c mediates anxiety-like behavior in mice.. Mol Psychiatry. 17(11):1054-5.

Lee AS, Gonzales KL, Lee A, Moosmang S, Hofmann F, Pieper AA, Rajadhyaksha AM.  2012.  Selective genetic deletion of cacna1c in the mouse prefrontal cortex.. Mol Psychiatry. 17(11):1051.

Schierberl K, Hao J, Tropea TF, Ra S, Giordano TP, Xu Q, Garraway SM, Hofmann F, Moosmang S, Striessnig J et al..  2011.  Cav1.2 L-type Ca²⁺ channels mediate cocaine-induced GluA1 trafficking in the nucleus accumbens, a long-term adaptation dependent on ventral tegmental area Ca(v)1.3 channels.. J Neurosci. 31(38):13562-75.

Ren J-Q, Jiang Y, Wang Z, McCarthy D, Rajadhyaksha AM, Tropea TF, Kosofsky BE, Bhide PG.  2011.  Prenatal L-DOPA exposure produces lasting changes in brain dopamine content, cocaine-induced dopamine release and cocaine conditioned place preference.. Neuropharmacology. 60(2-3):295-302.

Gregus AM, Tropea TF, Wang Y, Hauck SCR, Costa ACS, Rajadhyaksha AM, Inturrisi CE.  2010.  Deletion of the GluR5 subunit of kainate receptors affects cocaine sensitivity and preference.. Neurosci Lett. 468(3):186-9.

Kelly NH, Rajadhyaksha AD, Wright TM, Maher SA, Westrich GH.  2010.  High stress conditions do not increase wear of thin highly crosslinked UHMWPE.. Clin Orthop Relat Res. 468(2):418-23.

Giordano TP, Tropea TF, Satpute SS, Sinnegger-Brauns MJ, Striessnig J, Kosofsky BE, Rajadhyaksha AM.  2010.  Molecular switch from L-type Ca v 1.3 to Ca v 1.2 Ca2+ channel signaling underlies long-term psychostimulant-induced behavioral and molecular plasticity.. J Neurosci. 30(50):17051-62.

Rajadhyaksha AM, Elemento O, Puffenberger EG, Schierberl KC, Xiang JZ, Putorti ML, Berciano J, Poulin C, Brais B, Michaelides M et al..  2010.  Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosa.. Am J Hum Genet. 87(5):643-54.

Gregus AM, Inra CN, Giordano TP, Costa ACS, Rajadhyaksha AM, Inturrisi CE.  2010.  Spinal mediators that may contribute selectively to antinociceptive tolerance but not other effects of morphine as revealed by deletion of GluR5.. Neuroscience. 169(1):475-87.

Higgins JJ, Tal AL, Sun X, Hauck SCR, Hao J, Kosofosky BE, Rajadhyaksha AM.  2010.  Temporal and spatial mouse brain expression of cereblon, an ionic channel regulator involved in human intelligence.. J Neurogenet. 24(1):18-26.

Bogulavsky JJ, Gregus AM, Kim PT-H, Costa ACS, Rajadhyaksha AM, Inturrisi CE.  2009.  Deletion of the glutamate receptor 5 subunit of kainate receptors affects the development of morphine tolerance.. J Pharmacol Exp Ther. 328(2):579-87.

Higgins JJ, Hao J, Kosofsky BE, Rajadhyaksha AM.  2008.  Dysregulation of large-conductance Ca2+-activated K+ channel expression in nonsyndromal mental retardation due to a cereblon p.R419X mutation.. Neurogenetics. 9(3):219-23.

Tropea TF, Kosofsky BE, Rajadhyaksha AM.  2008.  Enhanced CREB and DARPP-32 phosphorylation in the nucleus accumbens and CREB, ERK, and GluR1 phosphorylation in the dorsal hippocampus is associated with cocaine-conditioned place preference behavior.. J Neurochem. 106(4):1780-90.

Covington HE, Tropea TF, Rajadhyaksha AM, Kosofsky BE, Miczek KA.  2008.  NMDA receptors in the rat VTA: a critical site for social stress to intensify cocaine taking.. Psychopharmacology (Berl). 197(2):203-16.

Giordano TP, Satpute SS, Striessnig J, Kosofsky BE, Rajadhyaksha AM.  2006.  Up-regulation of dopamine D(2)L mRNA levels in the ventral tegmental area and dorsal striatum of amphetamine-sensitized C57BL/6 mice: role of Ca(v)1.3 L-type Ca(2+) channels.. J Neurochem. 99(4):1197-206.

Guerriero RM, Rajadhyaksha A, Crozatier C, Giros B, Nosten-Bertrand M, Kosofsky BE.  2005.  Augmented constitutive CREB expression in the nucleus accumbens and striatum may contribute to the altered behavioral response to cocaine of adult mice exposed to cocaine in utero.. Dev Neurosci. 27(2-4):235-48.

Rajadhyaksha AM, Kosofsky BE.  2005.  Psychostimulants, L-type calcium channels, kinases, and phosphatases.. Neuroscientist. 11(5):494-502.

Eaton ME, Macías W, Youngs RM, Rajadhyaksha A, Dudman JT, Konradi C.  2004.  L-type Ca2+ channel blockers promote Ca2+ accumulation when dopamine receptors are activated in striatal neurons.. Brain Res Mol Brain Res. 131(1-2):65-72.

Rajadhyaksha A, Husson I, Satpute SS, Küppenbender KD, Ren JQ, Guerriero RM, Standaert DG, Kosofsky BE.  2004.  L-type Ca2+ channels mediate adaptation of extracellular signal-regulated kinase 1/2 phosphorylation in the ventral tegmental area after chronic amphetamine treatment.. J Neurosci. 24(34):7464-76.

Dudman JT, Eaton ME, Rajadhyaksha A, Macías W, Taher M, Barczak A, Kameyama K, Huganir R, Konradi C.  2003.  Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1.. J Neurochem. 87(4):922-34.

Macías W, Carlson R, Rajadhyaksha A, Barczak A, Konradi C.  2001.  Potassium chloride depolarization mediates CREB phosphorylation in striatal neurons in an NMDA receptor-dependent manner.. Brain Res. 890(2):222-32.

Leveque JC, Macías W, Rajadhyaksha A, Carlson RR, Barczak A, Kang S, Li XM, Coyle JT, Huganir RL, Heckers S et al..  2000.  Intracellular modulation of NMDA receptor function by antipsychotic drugs.. J Neurosci. 20(11):4011-20.

Rajadhyaksha A, Barczak A, Macías W, Leveque JC, Lewis SE, Konradi C.  1999.  L-Type Ca(2+) channels are essential for glutamate-mediated CREB phosphorylation and c-fos gene expression in striatal neurons.. J Neurosci. 19(15):6348-59.