Publications

Akuffo AA, Alontaga AY, Metcalf R, Beatty MS, Becker A, McDaniel JM, Hesterberg RS, Goodheart WE, Gunawan S, Ayaz M et al..  2018.  Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon.. J Biol Chem. 293(16):6187-6200.

Addy NA, Nunes EJ, Hughley SM, Small KM, Baracz SJ, Haight JL, Rajadhyaksha AM.  2018.  The L-type calcium channel blocker, isradipine, attenuates cue-induced cocaine-seeking by enhancing dopaminergic activity in the ventral tegmental area to nucleus accumbens pathway.. Neuropsychopharmacology.

Bavley CC, Rice RC, Fischer DK, Fakira AK, Byrne M, Kosovsky M, Rizzo BK, Del Prete D, Alaedini A, Morón JA et al..  2018.  Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase-mTORC1 Translational Pathway.. J Neurosci. 38(11):2780-2795.

Fischer DK, Rice RC, Rivera AMartinez, Donohoe M, Rajadhyaksha AM.  2017.  Altered reward sensitivity in female offspring of cocaine-exposed fathers.. Behav Brain Res. 332:23-31.

Xu J, Lu Z, Narayan A, Le Rouzic VP, Xu M, Hunkele A, Brown TG, Hoefer WF, Rossi GC, Rice RC et al..  2017.  Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine.. J Clin Invest. 127(4):1561-1573.

Kabir ZD, Lee AS, Burgdorf CE, Fischer DK, Rajadhyaksha AM, Mok E, Rizzo B, Rice RC, Singh K, Ota KT et al..  2017.  Cacna1c in the Prefrontal Cortex Regulates Depression-Related Behaviors via REDD1.. Neuropsychopharmacology.

Bavley CC, Fischer DK, Rizzo BK, Rajadhyaksha AM.  2017.  Cav1.2 channels mediate persistent chronic stress-induced behavioral deficits that are associated with prefrontal cortex activation of the p25/Cdk5-glucocorticoid receptor pathway.. Neurobiol Stress. 7:27-37.

Na ES, De Jesús-Cortés H, Martinez-Rivera A, Kabir ZD, Wang J, Ramesh V, Onder Y, Rajadhyaksha AM, Monteggia LM, Pieper AA.  2017.  D-cycloserine improves synaptic transmission in an animal model of Rett syndrome.. PLoS One. 12(8):e0183026.

Martínez-Rivera A, Hao J, Tropea TF, Giordano TP, Kosovsky M, Rice RC, Lee A, Huganir RL, Striessnig J, Addy NA et al..  2017.  Enhancing VTA Cav1.3 L-type Ca(2+) channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens.. Mol Psychiatry.

Burgdorf CE, Schierberl KC, Lee AS, Fischer DK, Van Kempen TA, Mudragel V, Huganir RL, Milner TA, Glass MJ, Rajadhyaksha AM.  2017.  Extinction of contextual cocaine memories requires Cav1.2 within D1R-expressing cells and recruits hippocampal Cav1.2-dependent signaling mechanisms. Journal Of Neuroscience.

Kabir ZD, Martinez-Rivera A, Rajadhyaksha AM.  2017.  From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms.. Neurotherapeutics. 14(3):588-613.

Marrone GF, Le Rouzic V, Varadi A, Xu J, Rajadhyaksha AM, Majumdar S, Pan Y-X, Pasternak GW.  2017.  Genetic dissociation of morphine analgesia from hyperalgesia in mice.. Psychopharmacology (Berl). 234(12):1891-1900.

Del Prete D, Rice RC, Rajadhyaksha AM, D'Adamio L.  2016.  Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.. J Biol Chem. 291(33):17209-27.

De Jesús-Cortés H, Rajadhyaksha AM, Pieper AA.  2016.  Cacna1c: Protecting young hippocampal neurons in the adult brain.. Neurogenesis (Austin). 3(1):e1231160.

Inan M, Zhao M, Manuszak M, Karakaya C, Rajadhyaksha AM, Pickel VM, Schwartz TH, Goldstein PA, Manfredi G.  2016.  Energy deficit in parvalbumin neurons leads to circuit dysfunction, impaired sensory gating and social disability.. Neurobiol Dis. 93:35-46.

Kabir ZD, Lee AS, Rajadhyaksha AM.  2016.  L-type Ca(2+) channels in mood, cognition and addiction: integrating human and rodent studies with a focus on behavioural endophenotypes.. J Physiol. 594(20):5823-5837.

Lee AS, De Jesús-Cortés H, Kabir ZD, Knobbe W, Orr M, Burgdorf C, Huntington P, McDaniel L, Britt JK, Hoffmann F et al..  2016.  The Neuropsychiatric Disease-Associated Gene cacna1c Mediates Survival of Young Hippocampal Neurons.. eNeuro. 3(2)

Mende M, Fletcher EV, Belluardo JL, Pierce JP, Bommareddy PK, Weinrich JA, Kabir ZD, Schierberl KC, Pagiazitis JG, Mendelsohn AI et al..  2016.  Sensory-Derived Glutamate Regulates Presynaptic Inhibitory Terminals in Mouse Spinal Cord.. Neuron. 90(6):1189-202.

Liu Y, Harding M, Pittman A, Dore J, Striessnig J, Rajadhyaksha A, Chen X.  2014.  Cav1.2 and Cav1.3 L-type calcium channels regulate dopaminergic firing activity in the mouse ventral tegmental area.. J Neurophysiol. 112(5):1119-30.

Ajamian M, Rajadhyaksha AM, Alaedini A.  2013.  Autism and Lyme disease--reply.. JAMA. 310(8):857.

Moeller S, Lau NM, Green PHR, Hellberg D, Higgins JJ, Rajadhyaksha AM, Alaedini A.  2013.  Lack of association between autism and anti-GM1 ganglioside antibody.. Neurology. 81(18):1640-1.

Lau NM, Green PHR, Taylor AK, Hellberg D, Ajamian M, Tan CZ, Kosofsky BE, Higgins JJ, Rajadhyaksha AM, Alaedini A.  2013.  Markers of Celiac Disease and Gluten Sensitivity in Children with Autism.. PLoS One. 8(6):e66155.

Ajamian M, Kosofsky BE, Wormser GP, Rajadhyaksha AM, Alaedini A.  2013.  Serologic markers of Lyme disease in children with autism.. JAMA. 309(17):1771-3.

Schierberl KC, Rajadhyaksha AM.  2013.  Stereotaxic microinjection of viral vectors expressing Cre recombinase to study the role of target genes in cocaine conditioned place preference.. J Vis Exp. (77)

Rajadhyaksha AM, Ra S, Kishinevsky S, Lee AS, Romanienko P, DuBoff M, Yang C, Zupan B, Byrne M, Daruwalla ZR et al..  2012.  Behavioral characterization of cereblon forebrain-specific conditional null mice: a model for human non-syndromic intellectual disability.. Behav Brain Res. 226(2):428-34.