Title | Potassium chloride depolarization mediates CREB phosphorylation in striatal neurons in an NMDA receptor-dependent manner. |
Publication Type | Journal Article |
Year of Publication | 2001 |
Authors | MacĂas W, Carlson R, Rajadhyaksha A, Barczak A, Konradi C |
Journal | Brain Res |
Volume | 890 |
Issue | 2 |
Pagination | 222-32 |
Date Published | 2001 Feb 02 |
ISSN | 0006-8993 |
Keywords | Animals, Calcium Channel Agonists, Calcium Channels, L-Type, Calcium-Calmodulin-Dependent Protein Kinase Type 1, Calcium-Calmodulin-Dependent Protein Kinases, Cells, Cultured, Corpus Striatum, Cyclic AMP Response Element-Binding Protein, DNA-Binding Proteins, Excitatory Amino Acid Antagonists, Fetus, Gene Expression Regulation, Hippocampus, Membrane Potentials, Neurons, Nuclear Proteins, Phosphorylation, Potassium Chloride, Pyrroles, Rats, Receptors, GABA, Receptors, N-Methyl-D-Aspartate, Serum Response Factor |
Abstract | Potassium chloride (KCl)-depolarization has been used to study the properties of L-type Ca2+ channel-mediated signal transduction in hippocampal neurons. Calcium influx through L-type Ca2+ channels stimulates a second messenger pathway that transactivates genes under the regulatory control of the Ca2+-and cyclic AMP-responsive element (CRE). Here, we show that in striatal neurons, but not in hippocampal neurons, CRE binding protein (CREB) phosphorylation and CRE-mediated gene expression after KCl-depolarization depends on functional NMDA receptors. This difference in NMDA receptor dependence is not due to different properties of L-type Ca2+ channels in either neuronal type, but rather to different neuron-intrinsic properties. Despite this variation, the second messenger pathway activated by KCl requires Ca2+/calmodulin (CaM) kinase for CREB phosphorylation in both neuronal types. We conclude that depolarization by KCl works differently in striatal and hippocampal neurons. |
Alternate Journal | Brain Res. |
PubMed ID | 11164788 |
PubMed Central ID | PMC4203340 |
Grant List | R01 DA007134 / DA / NIDA NIH HHS / United States R01 DA007134-14 / DA / NIDA NIH HHS / United States DA07134 / DA / NIDA NIH HHS / United States |