Submitted by def2008 on March 19, 2017 - 2:16pm
Title | Psychostimulants, L-type calcium channels, kinases, and phosphatases. |
Publication Type | Journal Article |
Year of Publication | 2005 |
Authors | Rajadhyaksha AM, Kosofsky BE |
Journal | Neuroscientist |
Volume | 11 |
Issue | 5 |
Pagination | 494-502 |
Date Published | 2005 Oct |
ISSN | 1073-8584 |
Keywords | Animals, Calcium Channels, L-Type, Central Nervous System Stimulants, Humans, Models, Molecular, Models, Neurological, Nucleus Accumbens, Phosphoric Monoester Hydrolases, Phosphotransferases, Signal Transduction, Substance-Related Disorders, Ventral Tegmental Area |
Abstract | There is growing evidence for the role of voltage-gated L-type Ca2+ channels in mediating aspects of the addictive properties of psychostimulants. L-type Ca2+ channels activate Ca2+ second-messenger pathways that regulate protein phosphorylation and thereby activation of target gene expression. Here the authors will review recent progress in our understanding of L-type Ca2+ channel-activated signal transduction pathways that contribute to molecular neuroadaptations evident following acute and chronic exposures to psychostimulants. |
DOI | 10.1177/1073858405278236 |
Alternate Journal | Neuroscientist |
PubMed ID | 16151049 |
PubMed Central ID | PMC2706980 |
Grant List | K01 DA014057 / DA / NIDA NIH HHS / United States K01 DA014057-05 / DA / NIDA NIH HHS / United States |