Submitted by def2008 on March 19, 2017 - 2:10pm
Title | Molecular components of striatal plasticity: the various routes of cyclic AMP pathways. |
Publication Type | Journal Article |
Year of Publication | 1998 |
Authors | Rajadhyaksha A, Leveque J, MacĂas W, Barczak A, Konradi C |
Journal | Dev Neurosci |
Volume | 20 |
Issue | 2-3 |
Pagination | 204-15 |
Date Published | 1998 |
ISSN | 0378-5866 |
Keywords | Animals, Benzazepines, Calcium, Colforsin, Corpus Striatum, Culture Techniques, Cyclic AMP, Cyclic AMP Response Element-Binding Protein, Dizocilpine Maleate, Dopamine, Dopamine Agonists, Excitatory Amino Acid Antagonists, Neuronal Plasticity, Phosphorylation, Rats, Rats, Sprague-Dawley, Receptors, N-Methyl-D-Aspartate |
Abstract | Neuroplasticity serves an important role for normal striatal function and in disease states. One route to neuroplasticity involves activation of the transcription factor cyclic 3', 5'-adenosine monophosphate (cyclic AMP) response element binding protein (CREB) by phosphorylation of the amino acid 133Ser. Dopamine and glutamate, the two predominant neurotransmitters in the striatum, induce CREB phosphorylation in primary cultures of rat striatum through cyclic AMP and Ca2+ pathways. Here we present the role of N-methyl-D-aspartate receptors and Ca2+ in cyclic AMP-mediated CREB phosphorylation. |
Alternate Journal | Dev. Neurosci. |
PubMed ID | 9691194 |
PubMed Central ID | PMC4205584 |
Grant List | R01 DA007134 / DA / NIDA NIH HHS / United States R01 DA007134-14 / DA / NIDA NIH HHS / United States |